Carpal tunnel syndrome is an entrapment neuropathy that is found in about 5 per cent of patients with systemic sclerosis (SSc) [1]. Some studies indicate that the syndrome is more common in the SSc patients (up to 25 per cent) [2], and study of Sukenic et al. [3] from 1987 indicated that the syndrome was a presenting symptom of the disease. In 2007-2009, we have observed 5 male patients with SSc who had a rapidly progressive disease.