ABCC8 Polymorphisms rs757110 and rs1801261 Association with Sulfonylurea Therapy of Iraqi Type 2 Diabetics
1
Depatment of Pharmacognosy, Kufa University College of Pharmacy, Iraq
2
Department of Lab. Investigation, Faculty of Science/ University of Kufa, Iraq
3
Department of Physiology, University of Kufa Faculty of Veterinary Medicine, Iraq
4
Department of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Najaf, Iraq, Iraq
Submission date: 2024-07-03
Final revision date: 2024-08-03
Acceptance date: 2024-09-16
Publication date: 2024-12-23
Corresponding author
Zubaida Alzubaidi
Department of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Najaf, Iraq, Iraq
Department of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Najaf, Iraq, Iraq
Wiadomości Lekarskie 2024;77(11):2317-2325
KEYWORDS
TOPICS
ABSTRACT
Aim:
Our study aimed to investigate the connection between the ABCC8 gene polymorphisms (rs1801261 and rs757110) and T2DM in the Iraqi Middle Euphrates region. Patients with type 2 diabetes were chosen because they were treated with glibenclamide and glimepiride.
Material and methods:
The groups of this case-control study are the control group obviously healthy persons included 400 (235 Male/165 Female) and 400 T2DM group (213 Male/ 187 Female). The FSG, HDL-Ch, Total-Ch, LDL-Ch, and Tgs are measured and genotyping of these two SNPs.
Results:
Our findings that FSG augmented in CA and AA codominant styles of rs757110. Moreover, there were decreased insulin and BMI significantly (p = 0.002 & 0.026 respectively) in CA and AA codominant patterns of rs757110. Likewise, glucose was high significantly (0.017) and reduced insulin and BMI (p = 0.001 & 0.013 respectively) in dominant pattern (CA+AA) of rs757110. As codominant pattern (of rs757110), AA carriers revealed significant (p = 0.03) risky (OR = 1.83) when adjustment with age, BMI and sex. Additionally, after controlling for gender, age, and dominant pattern, CA + AA carriers had a significant (p = 0.02) risk factor for diabetic disease (OR = 1.45). There was no correlation between rs1801261, and T2DM.
Conclusions:
The rs757110 related to less insulin excretion in T2DM of Iraqi Middle Euphrates population who received glimepiride and glibenclamide for diabetes treatment.
Our study aimed to investigate the connection between the ABCC8 gene polymorphisms (rs1801261 and rs757110) and T2DM in the Iraqi Middle Euphrates region. Patients with type 2 diabetes were chosen because they were treated with glibenclamide and glimepiride.
Material and methods:
The groups of this case-control study are the control group obviously healthy persons included 400 (235 Male/165 Female) and 400 T2DM group (213 Male/ 187 Female). The FSG, HDL-Ch, Total-Ch, LDL-Ch, and Tgs are measured and genotyping of these two SNPs.
Results:
Our findings that FSG augmented in CA and AA codominant styles of rs757110. Moreover, there were decreased insulin and BMI significantly (p = 0.002 & 0.026 respectively) in CA and AA codominant patterns of rs757110. Likewise, glucose was high significantly (0.017) and reduced insulin and BMI (p = 0.001 & 0.013 respectively) in dominant pattern (CA+AA) of rs757110. As codominant pattern (of rs757110), AA carriers revealed significant (p = 0.03) risky (OR = 1.83) when adjustment with age, BMI and sex. Additionally, after controlling for gender, age, and dominant pattern, CA + AA carriers had a significant (p = 0.02) risk factor for diabetic disease (OR = 1.45). There was no correlation between rs1801261, and T2DM.
Conclusions:
The rs757110 related to less insulin excretion in T2DM of Iraqi Middle Euphrates population who received glimepiride and glibenclamide for diabetes treatment.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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