Adenosine Triphosphate Binding Cassette transporters-G5 and G8-early diagnostic tools for cardiovascular disease in Human
1
Department of physiology, Faculty of medicine, University of Kufa, Al-Furat Teaching Hospital, Iraq, Iraq
2
Department of Microbiology, Faculty of Veterinary Medicine, University of Kufa, Iraq, Iraq
3
Oncology Center, Faculty of Medicine, University of Kufa, Iraq, Iraq
Submission date: 2022-10-30
Final revision date: 2023-11-13
Acceptance date: 2024-02-01
Publication date: 2024-03-30
Corresponding author
Amina A. B. Al-Dejeli
Department of physiology, Faculty of medicine, University of Kufa, Al-Furat Teaching Hospital, Iraq, Iraq
Department of physiology, Faculty of medicine, University of Kufa, Al-Furat Teaching Hospital, Iraq, Iraq
Wiadomości Lekarskie 2024;77(2):262-267
KEYWORDS
TOPICS
ABSTRACT
Aim:
Background Cholesterol is absolutely necessary for the physiological function of all living mammalian tissues, meanwhile abnormally elevation in blood cholesterol regarded as is a major risk factor for cardiovascular disease (CVD). Aim Adenosine triphosphate binding cassette transporters-G5 (ABC-G5) and G8 (ABCG8) Forman obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and sterols. Consistent with their function, ABCG5 and ABC-G8 are located on the apical membrane of enterocytes and hepatocytes.
Material and methods:
Materials and results: Data was collected in paper form and recorded from 100 personals suspected with CVS after take the case history and clinical signs in private clinical hospital and the serum was collected for measurements the activity of ABCG5 and ABCG5 by used ELISA reader and the results illustrated that activity of ABCG5 and ABCG5 in all aged groups.
Results:
Results: periods in patient person male and female significant decrease as compared with same age in same period of live, so that the researched depicted that can used the serum activity of ABCG5 and ABCG5 as a diagnostics tools for atherosclerotic cardiovascular disease.
Conclusions:
Conclusion: In this review, we identified areas of further exploration on cholesterol transport related with CVD risk and concluded that changes in the Adenosine Triphosphate Binding Cassette transporters mainly G5 and G8 early diagnostic tools for cardiovascular disease in Human. In this review, we correlated areas of farther disquisition on nutrient cholesterol and CVD threat, in the included trials, healthy grown-ups consumed high doses of dietary cholesterol.
Background Cholesterol is absolutely necessary for the physiological function of all living mammalian tissues, meanwhile abnormally elevation in blood cholesterol regarded as is a major risk factor for cardiovascular disease (CVD). Aim Adenosine triphosphate binding cassette transporters-G5 (ABC-G5) and G8 (ABCG8) Forman obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and sterols. Consistent with their function, ABCG5 and ABC-G8 are located on the apical membrane of enterocytes and hepatocytes.
Material and methods:
Materials and results: Data was collected in paper form and recorded from 100 personals suspected with CVS after take the case history and clinical signs in private clinical hospital and the serum was collected for measurements the activity of ABCG5 and ABCG5 by used ELISA reader and the results illustrated that activity of ABCG5 and ABCG5 in all aged groups.
Results:
Results: periods in patient person male and female significant decrease as compared with same age in same period of live, so that the researched depicted that can used the serum activity of ABCG5 and ABCG5 as a diagnostics tools for atherosclerotic cardiovascular disease.
Conclusions:
Conclusion: In this review, we identified areas of further exploration on cholesterol transport related with CVD risk and concluded that changes in the Adenosine Triphosphate Binding Cassette transporters mainly G5 and G8 early diagnostic tools for cardiovascular disease in Human. In this review, we correlated areas of farther disquisition on nutrient cholesterol and CVD threat, in the included trials, healthy grown-ups consumed high doses of dietary cholesterol.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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