Aerobic skin microbiota study in patients with paratraumatic eczema developed as a result of combat injuries
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National Academy of Sciences of Ukraine, State Establishment "Institute of Dermatology and Venereology National Academy of Sciences of Ukraine", Ukraine
Submission date: 2024-05-07
Final revision date: 2024-08-13
Acceptance date: 2024-12-09
Publication date: 2025-01-31
Corresponding author
Svitlana Dzhoraieva
National Academy of Sciences of Ukraine, State Establishment "Institute of Dermatology and Venereology National Academy of Sciences of Ukraine", Kharkiv, Ukraine
Wiadomości Lekarskie 2025;(1):45-52
KEYWORDS
TOPICS
ABSTRACT
Aim:
To establish taxonomic composition, population level and microecological indicators of the "macroorganism-microbiota" ecosystem by determining the expression levels of individual pathogenicity factors of microorganisms isolated from the skin areas of patients with paratraumatic eczema developed as a result of combat injuries
Material and methods:
Studied microbiologically eczematous lesions content in 54military men to determine the qualitative and quantitative composition of microbiocenosis to analyze the taxonomic composition, population-species level, microecological indicators and expression levels of individual pathogenicity factors.
Results:
The results indicate that most eczematized areas are contaminated with S.aureus (48.1% ) with the highest level of quantitative dominance. The rate of quantitative dominance of other strains is significantly lower: S.epidermidis – 2.56 times, S.haemolyticus – 4.56 times, S.pyogenes – 5.86 times, E.faecalis and K.pneumoniae – 20.56 times.When determining the sensitivity of S. aureus clinical strains to antibacterial drugs, we established high levels of sensitivity to mupirocin, fusidic acid, and oxazolidinones – 95.1%, 90.2%, and 87.8%, respectively. Moreover, S. aureus dominated among the strains with a high ability to form biofilms – 68.2%, with an average ability – S epidermidis, 28.8%.
Conclusions:
S.aureus is the leading pathogen in the infectious-allergic process with paratraumatic eczema according to the constancy index of each taxon, frequency of manifestation, Margalef's species richness index, Whittaker's species diversity, the value of Simpson's and Berger-Parter's species dominance indices, as well as the population level of each taxon, the coefficient of quantitative dominance and the coefficient of significance. We should consider this fact when prescribing therapy
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