Aim To develop clinical classification of liver cirrhosis, which can aid individualization and planning definitive treatment for this group of patients. Material and methods Computerized search of the literature was performed via PubMed using the following medical subject headings or keywords: "liver", "cirrhosis" and “classification”; or "liver", "cirrhosis" and “complications"; or "liver", "cirrhosis" and “treatment"; or "portal" ", "hypertension" and "complications”. Articles were independently evaluated by each author, the etiological, morphological and current clinical classifications of LC were analyzed, their advantages and disadvantages identified, and after discussion classification of LC was developed by consensus. Results The developed clinical classification include 5 stages of liver cirrhosis, assessment of portal hypertension type and related complications, complications of liver cirrhosis and their degree. Each point is briefly described according modern international guidelines for liver cirrhosis diagnosis and treatment. Clinical classification permits to perform clinical diagnosis, based of the presence of certain complications of the disease and their degree. Planning treatment of the patient is done according guidelines for treatment of the particular complications of the disease. Conclusions The developed clinical classification of liver cirrhosis will facilitate the planning of therapeutic tactics for each patient, allow to personalize the treatment of patients with this pathology.