Aim: The aim of our study was detection and correction of dysmenorrhea in teenage girls with autonomic dysfunction syndrome. Materials and Methods: The research group consisted of 37 teenage girls, aged 12-16 years, who were undergoing rehabilitation treatment with signs of dysmenorrhea and vegetative dysfunction syndrome. The study lasted for 2 years (2020-2021). A study of the variability of the heart rate at rest and under the conditions of an orthostatic test was carried out using the “Cardiolab” complex by the method of spectral analysis. Results: Analyzing the initial state of the autonomic nervous system in girls with menstrual cycle disorders, the primary predominance of the sympathetic nervous system in 33.3% of girls was revealed. Before treatment, autonomic reactivity was characterized by a hypersympathetic type in 44.4% of girls, by an asympathetic type in 22.3% of children. Spectral analysis at the beginning of treatment showed that high frequencies (HF) prevail in most girls (66.0%), which indicates an increased influence of the parasympathetic part of the autonomic nervous system, and 18.5% of girls have a balanced state of the autonomic nervous system. Predominance in the spectrum of LF and VLF components was found in 15.5%, which indicates the predominance of central humoral-metabolic ergotropic effects on heart rate variability. After the course of treatment an improvement in the condition of teenage girls was observed. Menstruation became less painful or painless at all, the duration and frequency of menstruation (from 1 to 3 days, on average 1.8±0.1) and blood loss decreased. The girls felt better, did not complain of dizziness and headache. Conclusions: According to the results of the study, it was found that the proposed course of treatment for teenage girls with a menstrual cycle disorder with signs of autonomic dysfunction contributed to the normalization of the cycle, improvement of the general condition of the girls.