Diet control and BMI impact on Metformin response in type 2 Diabetes mellitus patients
1
Department of Pharmacology and Therapeutic, Faculty of Medicine, University of Kufa, Iraq, Iraq
2
Department of Molecular Biology, Faculty of Science, University of Babylon, Babil, Iraq, Iraq
3
Department of Microbiology, Faculty of Medicine, University of Kufa, Najaf, Iraq, Iraq
Submission date: 2023-09-16
Final revision date: 2024-07-14
Acceptance date: 2024-07-17
Publication date: 2024-09-03
Corresponding author
Najah Rayish Hadi
Department of Pharmacology and Therapeutic, Faculty of Medicine, University of Kufa, Iraq, Iraq
Department of Pharmacology and Therapeutic, Faculty of Medicine, University of Kufa, Iraq, Iraq
Wiadomości Lekarskie 2024;77(8):1575-1581
KEYWORDS
TOPICS
ABSTRACT
Aim:
Background: An elevation in body fat is generally linked with increased chance of metabolic diseases occurrence such as type 2 diabetes mellitus, hypertension, and dyslipidaemia. Diet control and BMI (Body Mass Index) play crucial roles in the management of patients with Type 2 diabetes mellitus (T2DM). Aim: In our study we evaluate the impact of BMI and diet control on glycemic parameters in type 2 diabetic patients on metformin.
Material and methods:
Patients and Method: a cross-sectional study included 150 patients who met specific criteria, such as being between 30 and 70 years old, diagnosed with type 2 diabetes, and on a daily dose of 1000 mg metformin as a monotherapy for at least three months. Data collected included body mass index (BMI) and glycemic control parameters such as: glycated hemoglobin (HbA1c) levels, fasting blood glucose levels, fasting serum insulin levels, HOMA-IR, and insulin sensitivity. The patients according to their metformin response classified into two groups based on HbA1c as following: poor (HbA1c≥6.5% and good (HbA1c≤6.5%) responder’s patients.
Results:
Results: The statistical analysis suggests that there is no meaningful distinction in glycemic control parameters when comparing good and poor responders within specific BMI subgroups and among individuals practicing diet control. However, in a broader context, it is evident that glycemic control parameters tend to be lower in patients with lower BMI and those who are following a controlled diet.
Conclusions:
Conclusion: The correlation between diet control and BMI with glycemic control in diabetic patients, underscoring the significance of lifestyle adjustments in the management of diabetes.
Background: An elevation in body fat is generally linked with increased chance of metabolic diseases occurrence such as type 2 diabetes mellitus, hypertension, and dyslipidaemia. Diet control and BMI (Body Mass Index) play crucial roles in the management of patients with Type 2 diabetes mellitus (T2DM). Aim: In our study we evaluate the impact of BMI and diet control on glycemic parameters in type 2 diabetic patients on metformin.
Material and methods:
Patients and Method: a cross-sectional study included 150 patients who met specific criteria, such as being between 30 and 70 years old, diagnosed with type 2 diabetes, and on a daily dose of 1000 mg metformin as a monotherapy for at least three months. Data collected included body mass index (BMI) and glycemic control parameters such as: glycated hemoglobin (HbA1c) levels, fasting blood glucose levels, fasting serum insulin levels, HOMA-IR, and insulin sensitivity. The patients according to their metformin response classified into two groups based on HbA1c as following: poor (HbA1c≥6.5% and good (HbA1c≤6.5%) responder’s patients.
Results:
Results: The statistical analysis suggests that there is no meaningful distinction in glycemic control parameters when comparing good and poor responders within specific BMI subgroups and among individuals practicing diet control. However, in a broader context, it is evident that glycemic control parameters tend to be lower in patients with lower BMI and those who are following a controlled diet.
Conclusions:
Conclusion: The correlation between diet control and BMI with glycemic control in diabetic patients, underscoring the significance of lifestyle adjustments in the management of diabetes.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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