Aim: The digital transformation of healthcare is revolutionizing the management of medical institutions, improving operational efficiency, patient outcomes, and data security. With the increasing complexity of healthcare systems, the integration of cutting-edge technologies such as Artificial Intelligence. The COVID-19 pandemic significantly accelerated digital transformation, compelling healthcare institutions to adopt telemedicine, AI-assisted diagnostics, and cloud-based medical records to meet growing patient demands and resource constraints. The rapid digital transformation of healthcare is driven by advancements in Artificial Intelligence (AI), blockchain, the Internet of Things (IoT), and Big Data. This review article aims to analyze the objectives and implications of digital transformation in medical institutions, focusing on the integration of AI, blockchain, and IoT in hospital management. Materials and methods: The methodological approach for this review article focuses on synthesizing existing literature to examine the role of Artificial Intelligence (AI), blockchain, the Internet of Things (IoT), and Big Data in the digital transformation of healthcare management. Results and Conclusions: The integration of Artificial Intelligence (AI), Blockchain, Internet of Things (IoT), and Big Data has demonstrated significant improvements in healthcare management, enhancing efficiency, patient outcomes, and data security.