Aim:
To evaluate the effectiveness of selective serotonin reuptake inhibitors (SSRIs) to the treatment of patients with premature ejaculation who have been affected by combat actions.

Material and methods:
Results of an examination of 50 men injured as a result of hostilities, with sexual dysfunction and complaints of premature ejaculation. Patients were divided into smaller subgroups depending on the selected serotonin reuptake inhibitors, which they received for at least 1.5 months: sertraline (n=14), paroxetine (n=12), citalopram (n=12), venlafaxine (n=12).

Results:
After treatment with all serotonin reuptake inhibitors, reactive and personal anxiety symptoms, as assessed by the Spielberger-Hanan scale, were objectively reduced in men. Only treatment with paroxetine and citalopram resulted in a likely reduction in depressive symptoms in men with premature ejaculation, Paroxetine and sertraline appeared to be relatively balanced drugs with moderate efficacy but relatively few side effects. The lack of a «gold standard» among serotonin reuptake inhibitor drugs for the treatment of premature ejaculation on the Ukrainian market necessitates the search for new, more effective drugs with the possibility of flexible use.

Conclusions:
The study demonstrates that the neurotransmitter serotonin plays a key role in the modulation of ejaculation, as the use of reuptake inhibitors increases the intravaginal latency to ejaculation. Among the selective serotonin reuptake inhibitors, venlafaxine was found to be the most effective.