Aim: To determine the peculiarities of the course of pregnancy and childbirth in mothers whose children suffer from abnormal uterine bleeding during puberty. Materials and Methods: The study involved examination of 95 girls aged 10 to 18, who were divided into clinical groups: clinical group I (main (MG)) – 65 girls with abnormal uterine bleeding during puberty, clinical group II (control (CG)) – 30 somatically healthy girls, who came to clinic for a medical checkup. Results: Assessment of histories on the condition of mothers during pregnancy and childbirth in the MG showed existing gestational disorders. Thus, in MG, mothers were 17 times more likely to suffer from extragenital disorders, 15–20 times more likely to suffer from colds, 10 times more likely to suffer from toxicosis in the first half of pregnancy and preeclampsia, and 8 times more often to have placental dysfunction. Childbirths of mothers of MG girls were characterized by a pathological course: premature discharge of amniotic fluid, weakness of labor, preeclampsia during childbirth, fetal distress. In MG, operative deliveries were resorted to 13 times more often. In addition, birth trauma occurred in 15.38% of newborns, asphyxia at birth in 41.53%, and hypoxic-ischemic brain damage in 23.07%. Conclusions: During the analysis of history data, peculiarities of the course of pregnancy and childbirth in mothers whose children suffer from abnormal uterine bleeding during puberty were revealed. The mothers of these girls have a complicated course of pregnancy and childbirth. Pathological effects on the fetus in the ante- and intranatal periods create the basis for the development of pathological puberty, which can manifest itself in the form of abnormal uterine bleeding.