Genetic Polymorphism of CYP11B2 Gene in Iraqi Patient with Essential Hypertension
1
Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Iraq, Iraq
2
Department of Pharmacology and Therapeutics, College of pharmacy, University of Al-Qadisiyah, Iraq, Iraq
Submission date: 2023-08-07
Final revision date: 2024-04-19
Acceptance date: 2024-07-17
Publication date: 2024-11-03
Corresponding author
Israa Mohammed Mahdy
Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Iraq, Iraq
Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Iraq, Iraq
Wiadomości Lekarskie 2024;77(9):1726-1732
KEYWORDS
TOPICS
ABSTRACT
Aim:
To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their effect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province.
Material and methods:
This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist. There were a total of 90 participants, 37 males and 53 women. Aldosterone and renine levels in the plasma were determined from blood samples given voluntarily by patients undergoing genetic testing.
Results:
Regarding rs4539 the most frequent allele was T (112, 62%) while the most frequent genotype was TC (54, 60%). Regarding rs1799998 the most frequent allele was G (97, 54%) while the most frequent genotype was AG (49, 54%).
Conclusions:
There was no significant relationship between rs1799998 (A344>G) and rs4539 (T2718C) with systolic and diastolic blood pressure in Iraqi patient with essential hypertension.
To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their effect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province.
Material and methods:
This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist. There were a total of 90 participants, 37 males and 53 women. Aldosterone and renine levels in the plasma were determined from blood samples given voluntarily by patients undergoing genetic testing.
Results:
Regarding rs4539 the most frequent allele was T (112, 62%) while the most frequent genotype was TC (54, 60%). Regarding rs1799998 the most frequent allele was G (97, 54%) while the most frequent genotype was AG (49, 54%).
Conclusions:
There was no significant relationship between rs1799998 (A344>G) and rs4539 (T2718C) with systolic and diastolic blood pressure in Iraqi patient with essential hypertension.
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| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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