Aim:
To give epidemiological and clinical characteristics of the morbidity of Lyme borreliosis in Ivano-Frankivsk region for the period of 2000-2022 years.

Material and methods:
There were used annual reports (form №1) from the State Institution “Ivano-Frankivsk Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine” and 200 of “Medical records of inpatients” (form 003/о) of the Ivano-Frankivsk Regional Clinical Infectious Diseases Hospital for 2000-2022 years.

Results:
The morbidity of Lyme borreliosis in the Ivano-Frankivsk region has been permanently increasing since 2000. Natural foci have been identified, the number of which is increasing every year. There was noted late admission of patients to the Infectious Disease Hospital from the beginning of the disease, mainly at the stage of migratory annular erythema. There were almost no phenomena of intoxication and fever during the acute period. There were often observed the phenomena of hepatosis, joint damage and manifestations of the nervous system at the disseminated and chronic stages.

Conclusions:
All landscape zones of Ivano-Frankivsk region are enzootic regarding Lyme borreliosis. Over the last 10 years in the region there is a tendency to a sharp increase of Lyme borreliosis morbidity. The clinical peculiarities of the disease in Ivano-Frankivsk region are: the absence of intoxication at the stage of migratory erythema, the phenomena of hepatosis. During the second and third stages of the disease there are polymorphic symptoms: recurrent erythema, damage of the retina, joints, liver, nervous system.