ABSTRACT Introduction: Portal hypertension can have both sinusoidal and presinusoidal factors that cause a number of complications. These include diuretic-resistant ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, and variceal bleeding. Their combination requires multidirectional treatment, is not always successful and is accompanied by high mortality. Aim:To evaluate the peculiarities of the course of complications and the provision of care for portal hypertension associated with the development of diuretic-resistant ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, and variceal bleeding. Review and disscusion:Portal hypertension, which causes such complications as diuretic-resistant ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, variceal bleeding, is evidence of decompensation of the process and in most cases corresponds to Child-Pugh classis B and C.Diagnosis of these conditions is difficult, and treatment requires taking into account pathological mechanisms that affect the function of the liver, spleen, kidneys, cardiovascular and pulmonary systems. Conclusions: Diagnosis and treatment of patients with complicated portal hypertension requires a multidisciplinary approach, which is due to the diverse pathophysiological process of portal hypertension. The possibilities of providing emergency care to this category of patients depend on the level of medical training of the staff, the possibilities of medical and technical support in the provision of interventional care, the ineffectiveness of which necessitates surgical treatment using minimally invasive technologies.