Profile of antibiotic resistance of the main infectious contaminants on the wound surface of wounded men in the Russian-Ukrainian war
 
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1
Department of Microbiology, Danylo Halytsky Lviv National Medical University, Ukraine
 
2
Department of Urology, Danylo Halytsky Lviv National Medical University, Ukraine
 
3
Department of Disaster Medicine and Military Medicine, Danylo Halytsky Lviv National Medical University, Ukraine
 
4
Biophysics Department, Danylo Halytsky Lviv National Medical University, Ukraine
 
5
Department of Normal Anatomy, Danylo Halytsky Lviv National Medical University, Ukraine
 
6
Department of Medical Biology, Danylo Halytsky Lviv National Medical University, Ukraine
 
 
Submission date: 2024-06-04
 
 
Acceptance date: 2024-12-09
 
 
Publication date: 2025-02-28
 
 
Corresponding author
Oksana Melnyk   

Department of Microbiology, Danylo Halytsky Lviv National Medical University, Ukraine
 
 
Wiadomości Lekarskie 2025;(2):295-302
 
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ABSTRACT
Aim:
To study the spectrum of antibiotic resistance of causative agents of wound infection in wounded men at the stage of specialized medical care

Material and methods:
Retrospective analysis of the results of culture of wound secretions on chromogenic media. The research involved 113 samples of biomaterial from 85 wounded. Sensitivity of antibiotics was studied by the Kirby-Bauer method

Results:
Analysis of the microflora of the wound surface made it possible to determine the dominance of gram-negative bacteria, they were isolated in 80% of cases. The microbial spectrum of gram-negative bacteria is represented by Pseudomonas aeruginosa – 31 isolates, Acinetobacter baumannii – 29 isolates, Enterobacter aerogenes – 21 isolates, Proteus vulgaris – 13 isolates, Escherichia coli – 7 isolates, Enterobacter cloacae – 5 isolates, Klebsiella pneumoniae – 7 isolates and gram-positive bacteria Staphylococcus aureus – 5 isolates, Enterococcus fecalis - 32 isolates. Among all tested isolates of gram-negative non-fermenting bacteria and enterobacteria, the highest sensitivity was observed to colomycin and polymyxin B, from 60 to 80%. When analyzing of antibiotic sensitivity of Klebsiella pneumoniae and Acinetobacter baumannii, it was found that these pathogens retain 80-100% of their actual antibiotic sensitivity to polymyxins.

Conclusions:
Gram-negative strains isolated from wound infection are sensitive to antibiotics: 70% to polymyxins (colistin), 30% to aminoglycosides (amikacin), 24-16% to cephalosporins (cefoperazone-sulbactam/cefoperazone-avibactam).
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