Aim:
The large loop excision of the transformation zone procedure is the most commonly used excisional method for treating cervical precancerous lesions. This study aimed to investigate the impact of the following prognostic factors: age; parity; menstrual status (premenopausal, postmenopausal); histological result of targeted biopsy -LSIL,HSIL; adequacy of colposcopic examination; transformation zone type; type of cervical lesion (type 1, 2, 3); colposcopic diagnosis/impression; lesion size - up to 1/3, up to 2/3 andover 2/3 of cervical circumference for the HSIL result in the specimen after loop electrosurgical excision (LLETZ) procedure.

Material and methods:
This is a prospective study (01.01.2017 – 31.07. 2021) including 189 patients with cervical precancerous lesions received LLETZ treatment One gynaecologic oncologist performed video colposcopy, targeted biopsy, and LLETZ. One histopathologist diagnosed histological specimens from the biopsy and LLETZ procedure

Results:
We found a statistically significant correlation between the histological result of the targeted biopsy factor and the colposcopic diagnosis factor concerning the final histological result of LLETZ. The cervical lesion size factor and cervical lesion type factor have prognostic significance for the histological outcome following LLETZ.

Conclusions:
The histological result of targeted biopsy and colposcopic diagnosis are significant factors for the final histological result after LLETZ. Cervical lesion invasion into the endocervical canal is a prognostic factor for HSIL, and its invisible borders – for carcinoma (in situ or microinvasive/invasive). Lesion size up to 1/3 of the cervix is a prognostic factor for LSIL and large lesions (2/3 of the cervix) – for HSIL and cervical cancer (in situ, microinvasive/invasive).