Mucormycosis is a serious life-threatening opportunistic infection which is characterized by various clinical and morphological manifestations, rapid pro gression, unpredictable course and high mortality. The development of mycormycosis depends on the metabolic and immune status of the human body. The authors conducted a clinical and morphological analysis of the case of rhinocerebral mucormycosis in a patient who was diagnosed lifetime, but despite a set of therapeutic and surgical measures led to death, which was due to the severity of the pathology, late hospitalization of the patient and the presence of comorbidities (type 1 diabetes mellitus and post-COVID-19 syndrome). The clinical case presented by the authors raises the issue of the need to increase physicians’ awareness about the rhinocerebral form of mucormycosis, improve early diagnostic methods and find effective approaches to therapeutic and surgical treatment of this pathology.