Aim:
We reported the case of tonsillitis treatment in a 17-years-old boy with non-antibiotic chemicals, phages preparate, plant derived products and benzathine phenoxymethylpenicillin.

Material and methods:
The antimicrobial agents for treatment of tonsillitis in the patient were selected on the basis of their activity in vitro against a disease agent, the group A β-hemolytic strain Streptococcus pyogenes BS1, isolated from tonsils.

Case report:
The Streptococcus pyogenes BS1, isolated from 17 years old boy with acute tonsillitis, was susceptible in vitro to β-lactams,  fluoroquinolones, cephems, however, resistant to clindamycin, spiramycin,  gentamicin, erythromycin, tetracycline and sulfamethoxazole/trimethoprim combination.       In vitro non-antibiotic preparations “Stomatidin”, “Chlorophyllipt” and phages of “Pyofag” manifested antimicrobial activity comparable to that of antibiotics.        However, in patient the “Stomatidin”, “Chlorophyllipt” and “Pyofag” were less effective than benzathine phenoxymethylpenicillin. The patient recovered with use of this antibiotic and Calendula flower extract as an local anti-inflammatory agent.

Summary:
The positive effects of non-antibiotics “Stomatidin”, “Chlorophyllipt” and phages of “Pyofag” on patient health correlate with their activity in vitro, however, they were less effective in fighting of streptococcal tonsillitis infection than antibiotic benzathine phenoxymethylpenicillin. Regarding possible side effects of the antibiotics use, the non-antibiotic preparations can be applied first against streptococcal tonsillitis. If not active enough in patients, they can be substituted or supplemented by antibiotic therapy.