Abstract: The given study draws on there view of materials and sources highlighting recent available research finding sand is aimed at analysing the latest advancements in the research on the function and dysfunction of mitochondria, which is recognized to be one of the crucial factors in the initiation and progression of atherosclerosis.Understanding the mechanism of mitochondrial dysfunction in cardiovascular diseases is an important challenge for the development of directly mitochondria-targeted strategies in approaching the issue of accountability for cardiovascular disorder risks. Mitochondrial dysfunction is associated with oxidative stress, calcium dyshomeostasis, defective ATP synthesis, and induction of the permeability transition pore. Therefore, therapy aimed at preventing these types of damages is beneficial and can be used in the treatment of atherosclerosis.The development of drugs with enhanced antioxidant activity, specifically targeting mitochondria, is crucial for approaches in the treatment of cardiovascular diseases wherein oxidative stress is highly implicated.