Three cases of fatal postoperative thromboembolic complications in patients with liver cirrhosis and bleeding from esophageal varicose veins after COVID - 19
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1
surgery department, BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE, Ukraine
2
Department of Surgery, Bogomolets National Medical University, Ukraine
Submission date: 2023-11-13
Final revision date: 2024-05-19
Acceptance date: 2024-07-17
Publication date: 2024-09-03
Corresponding author
Diana Vitalievna Rudyk
surgery department, BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE, T. Shevchenko Boulevard, 13,, 01601, Kyiv, Ukraine
Wiadomości Lekarskie 2024;77(8):1627-1632
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ABSTRACT
Aim:
The purpose of these clinical cases is to demonstrate patients with cirrhosis with bleeding from esophageal varices who developed fatal postoperative thromboembolic complications due to previous Covid 19.
Material and methods:
In this article, we would like to present the stories of 3 patients with cirrhosis and variceal bleeding who had covid 19 pneumonia shortly before the onset of variceal bleeding and whose postoperative period was complicated by fatal thrombosis or thromboembolic complications.
Case report:
Coronavirus disease (COVID-19), which broke out in China and caused a devastating pandemic worldwide, is associated with a significantly increased risk of thrombotic complications, especially pulmonary embolism. During the COVID-19 pandemic, investigations have reported a high incidence of venous thromboembolic (VTE) events in hospitalized patients with COVID-19, often despite thromboprophylaxis. Current recommendations for thromboprophylaxis are based on randomized clinical trials, which usually exclude patients at а potentially high risk of hemorrhagic complications. This category includes patients with liver cirrhosis complicated by variceal bleeding, thrombocytopenia, and coagulopathy. We present three patients who suffered severe covid pneumonia and were hospitalized with acute variceal bleeding, who developed fatal thromboembolic complications in the postoperative period.
Summary:
Rebalanced hemostasis in patients with liver disease is unreliable and may shift toward hemorrhage or thrombosis, depending on coexisting circumstantial risk factors.
Patients with liver cirrhosis and variceal bleeding with previous COVID-19 infection require special attention to prevent thromboembolic complications. However, in this category of patients, the use of anticoagulants requires caution and should be selected individually, taking into account the risks of thrombosis and rebleeding.