Treatment of Delusional Ideas: Analyzing the Effectiveness of Pharmacotherapy and Psychotherapeutic Methods
 
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Department of Psychiatry, Psychotherapy and Medical Psychology, Shupyk National Healthcare University of Ukraine, Ukraine
 
 
Submission date: 2024-02-22
 
 
Acceptance date: 2024-11-04
 
 
Publication date: 2024-12-30
 
 
Corresponding author
Olha Zahariichuk   

Department of Psychiatry, Psychotherapy and Medical Psychology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
 
 
Wiadomości Lekarskie 2024;77(12):2501-2509
 
KEYWORDS
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ABSTRACT
Aim: to investigate the etiology, pathogenesis, and effectiveness of pharmacotherapy and psychotherapeutic modalities of delusions in Schizophrenia spectrum and other Psychotic Disorders. Methods: In our study, we included English-language studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library conducted until January 2024 using the following keywords “delusions”, “Schizophrenia spectrum and other Psychotic Disorders”, “pharmacotherapy”, “psychotherapy”, and “antipsychotics”. Scientific novelty: There is already published evidence that has studied Schizophrenia spectrum disorders from definition to treatment. However, a lack of studies has identified a comprehensive analysis of the available therapies for managing this condition. In our article, we studied Schizophrenia spectrum disorders and evaluated the role of both pharmacotherapy and psychotherapy in managing this condition. Conclusion: The management of delusions requires combined pharmacotherapy and psychotherapy. Cognitive therapy combined with antipsychotics has a significant beneficial role in improving delusions. Further randomized trials are required to properly estimate the efficacy of the available therapies and determine the first-choice therapy in patients with different categories of Schizophrenia spectrum disorders.
REFERENCES (56)
1.
Currell EA, Werbeloff N, Hayes JF, Bell V. Cognitive neuropsychiatric analysis of an additional large Capgras delusion case series. Cognitive Neuropsychiatry. 2019 Mar;24(2):123–34.
 
2.
Rootes-Murdy K, Goldsmith DR, Turner JA. Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review. Frontiers in Integrative Neuroscience. 2022 Jan;15.
 
3.
Altamura AC, Maggioni E, Dhanoa T, Ciappolino V, Paoli RA, Cremaschi L, et al. The impact of psychosis on brain anatomy in bipolar disorder: A structural MRI study. Journal of Affective Disorders. 2018 Jun;233:100–9.
 
4.
Warren N, O’Gorman C, Hume Z, Kisely S, Siskind D. Delusions in Parkinson’s Disease: A Systematic Review of Published Cases. Neuropsychology Review. 2018 Sep;28(3):310–6.
 
5.
Joseph SM, Siddiqui W. Delusional Disorder. The Medical Basis of Psychiatry: Fourth Edition. 2023 Mar;137–44.
 
6.
Lazorko O, Overchuk V, Zhylin M, Bereziak K, Savelchuk I. Modern types of psychological correction and their practical application. Systematic Reviews in Pharmacy. 2020;11(11).
 
7.
Bell V, Raihani N, Wilkinson S. Derationalizing Delusions. Clinical Psychological Science. 2021 Jan;9(1):24–37.
 
8.
Picardi A, Fonzi L, Pallagrosi M, Gigantesco A, Biondi M. Delusional Themes Across Affective and Non-Affective Psychoses. Frontiers in Psychiatry. 2018 Apr;9.
 
9.
Serhiyenko V, Holzmann K, Holota S, Derkach Z, Nersesyan A, Melnyk S, Chernysh O, Yatskevych O, Mišík M, Bubalo V, Strilbytska O, Vatseba B, Lushchak O, Knasmüller S, Cherkas A. An exploratory study of physiological and biochemical parameters to identify simple, robust and relevant biomarkers for therapeutic interventions for PTSD: study rationale, key elements of design and a context of war in Ukraine. Proc Shevchenko Sci Soc Med Sci [Internet]. 2022Dec.30 [cited 2024Jan.14];69(2). Available from: https://mspsss.org.ua/index.ph....
 
10.
Kumar D. Promoting insight into delusions: Issues and challenges in therapy. International Journal of Psychiatry in Clinical Practice. 2020 Jun;24(2):208–13.
 
11.
Arsovski D, Prodanovska-Stojchevska V, Filov I, Rajchanovska D, Petkovska D, Jovanovska T. Restoring Control: Bladder and Bowel Function Assessment in Multiple Sclerosis Rehabilitation. Futurity Medicine. 2023 Jun;2(2 SE-Articles):4–17.
 
12.
Humpston CS, Adams RA, Benrimoh D, Broome MR, Corlett PR, Gerrans P, et al. From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses. Schizophrenia Bulletin. 2019 Feb;45(Supplement_1):S56–66.
 
13.
Muñoz-Negro JE, Ibáñez-Casas I, de Portugal E, Lozano-Gutiérrez V, Martínez-Leal R, Cervilla JA. A Psychopathological Comparison between Delusional Disorder and Schizophrenia. The Canadian Journal of Psychiatry. 2018 Jan;63(1):12–9.
 
14.
Lancellotta E, Bortolotti L. Are clinical delusions adaptive? WIREs Cognitive Science. 2019 Sep;10(5).
 
15.
González-Rodríguez A, Seeman M V. Differences between delusional disorder and schizophrenia: A mini narrative review. World Journal of Psychiatry. 2022 May;12(5):683–92.
 
16.
Kalayasiri R, Kraijak K, Mutirangura A, Maes M. Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia. Schizophrenia Research. 2019 Jun;208:221–7.
 
17.
Hallak J, de Paula A, Chaves C, Bressan R, Machado-de-Sousa J. An Overview on the Search for Schizophrenia Biomarkers. CNS & Neurological Disorders - Drug Targets. 2015 Oct 8;14(8):996–1000.
 
18.
Kirkbride JB, Errazuriz A, Croudace TJ, Morgan C, Jackson D, Boydell J, et al. Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses. PloS one [Internet]. 2012 Mar 22 [cited 2024 Jan 20];7(3). Available from: https://pubmed.ncbi.nlm.nih.go....
 
19.
Baig S. Change in physical and mental health due to aging: future perspective. Futurity Medicine [Internet]. 2023 Mar 30 [cited 2023 Dec 11];2(1):13–23. Available from: https://futurity-medicine.com/....
 
20.
Ilina-Stohniienko V, Malets M. Regarding the modernisation of medical care system for victims of armed conflicts (Ukrainian experience). Futurity Medicine. 2022 Sep;1(3 SE-Articles):35–49.
 
21.
Mendez I, Axelson D, Castro-Fornieles J, Hafeman D, Goldstein TR, Goldstein BI, et al. Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study. Journal of the American Academy of Child & Adolescent Psychiatry. 2019 May;58(5):534-543.e6.
 
22.
Gawęda Ł, Staszkiewicz M, Balzan RP. The relationship between cognitive biases and psychological dimensions of delusions: The importance of jumping to conclusions. Journal of Behavior Therapy and Experimental Psychiatry. 2017 Sep;56:51–6.
 
23.
Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: An update for the 21 st century. Journal of Psychopharmacology. 2015 Feb;29(2):97–115.
 
24.
Carota A, Bogousslavsky J. Neurology versus Psychiatry? Hallucinations, Delusions, and Confabulations. In 2019. p. 127–40.
 
25.
Hany M, Rehman B, Azhar Y, Chapman J. Schizophrenia. StatPearls [Internet]. 2023 Mar 20 [cited 2024 Jan 19]; Available from: https://www.ncbi.nlm.nih.gov/b....
 
26.
Mari V, Georgiadi A, Maris A, Gkolia I. Acute polymorphic psychosis: An interesting case report. European Psychiatry [Internet]. 2021 Apr [cited 2024 Jan 19];64(Suppl 1):S811. Available from: /pmc/articles/PMC9480394/?report=abstract.
 
27.
Wy TJP, Saadabadi A. Schizoaffective Disorder. StatPearls [Internet]. 2023 Mar 27 [cited 2024 Jan 19]; Available from: https://www.ncbi.nlm.nih.gov/b....
 
28.
Fariba KA, Fawzy F. Delusions. Encyclopedia of Human Behavior: Second Edition. 2022 Sep;667–73.
 
29.
Paolini E, Moretti P, Compton MT. Delusions in first-episode psychosis: Principal component analysis of twelve types of delusions and demographic and clinical correlates of resulting domains. Psychiatry Research. 2016 Sep;243:5–13.
 
30.
McKay R. Measles, magic and misidentifications: a defence of the two-factor theory of delusions. Cognitive Neuropsychiatry. 2019 May;24(3):183–90.
 
31.
McLean BF, Mattiske JK, Balzan RP. Association of the Jumping to Conclusions and Evidence Integration Biases With Delusions in Psychosis: A Detailed Meta-analysis. Schizophrenia Bulletin. 2016 May;sbw056.
 
32.
Qian W, Fischer CE, Churchill NW, Kumar S, Rajji T, Schweizer TA. Delusions in Alzheimer Disease are Associated With Decreased Default Mode Network Functional Connectivity. The American Journal of Geriatric Psychiatry. 2019 Oct;27(10):1060–8.
 
33.
Looijestijn J, Blom JD, Aleman A, Hoek HW, Goekoop R. An integrated network model of psychotic symptoms. Neuroscience & Biobehavioral Reviews. 2015 Dec;59:238–50.
 
34.
Peach N, Alvarez‐Jimenez M, Cropper SJ, Sun P, Bendall S. Testing models of post‐traumatic intrusions, trauma‐related beliefs, hallucinations, and delusions in a first episode psychosis sample. British Journal of Clinical Psychology. 2019 Jun;58(2):154–72.
 
35.
Trotta A, Iyegbe C, Yiend J, Dazzan P, David AS, Pariante C, et al. Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis. Schizophrenia Research. 2019 Mar;205:51–7.
 
36.
Kataoka H, Sugie K. Delusional Jealousy (Othello Syndrome) in 67 Patients with Parkinson’s Disease. Frontiers in Neurology. 2018 Mar;9.
 
37.
Leffa DT, Panzenhagen AC, Salvi AA, Bau CHD, Pires GN, Torres ILS, et al. Systematic review and meta-analysis of the behavioral effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Neuroscience & Biobehavioral Reviews. 2019 May;100:166–79.
 
38.
Ansari MN, Bragg BN. Delusions of Parasitosis. StatPearls Publishing; 2023.
 
39.
Hussain N. The correlation between risk factors of COVID-19 and nervous system damage: Pakistan based Analysis. Futurity Medicine. 2022 Sep;22–9.
 
40.
Tsekhmister Y, Stepanenko V, Konovalova T, Tsekhmister B. Analysis of Physicochemical Natures of Modern Artifacts in MRI. International Journal of Online and Biomedical Engineering (iJOE). 2022 Mar;18(03):89–100.
 
41.
Bailey T, Alvarez-Jimenez M, Garcia-Sanchez AM, Hulbert C, Barlow E, Bendall S. Childhood Trauma Is Associated With Severity of Hallucinations and Delusions in Psychotic Disorders: A Systematic Review and Meta-Analysis. Schizophrenia Bulletin. 2018 Aug;44(5):1111–22.
 
42.
Vovchenko O, Leonova I, Soroka I, Klymenko I, Tsekhmister Y. The Impact of Emotional Intelligence on the Academic Performance of Students with Intellectual Disabilities in Inclusive Education. Journal of Intellectual Disability - Diagnosis and Treatment. 2022 Aug;10(4):187–96.
 
43.
Mehl S, Hesse K, Schmidt AC, Landsberg MW, Soll D, Bechdolf A, et al. Theory of mind, emotion recognition, delusions and the quality of the therapeutic relationship in patients with psychosis – a secondary analysis of a randomized-controlled therapy trial. BMC Psychiatry. 2020 Dec;20(1):59.
 
44.
Drummond N, McCleary L, Freiheit E, Molnar F, Dalziel W, Cohen C, et al. Antidepressant and antipsychotic prescribing in primary care for people with dementia. Canadian family physician Medecin de famille canadien. 2018 Nov;64(11):e488–97.
 
45.
Jennings AA, Guerin N, Foley T. Development of a tool for monitoring the prescribing of antipsychotic medications to people with dementia in general practice: a modified eDelphi consensus study. Clinical Interventions in Aging. 2018 Oct;Volume 13:2107–17.
 
46.
Faden J, Citrome L. Resistance is not futile: treatment-refractory schizophrenia – overview, evaluation and treatment. Expert Opinion on Pharmacotherapy. 2019 Jan;20(1):11–24.
 
47.
Haddad PM, Correll CU. The acute efficacy of antipsychotics in schizophrenia: a review of recent meta-analyses. Therapeutic Advances in Psychopharmacology. 2018 Nov;8(11):303–18.
 
48.
Muñoz-Negro JE, Gómez-Sierra FJ, Peralta V, González-Rodríguez A, Cervilla JA. A systematic review of studies with clinician-rated scales on the pharmacological treatment of delusional disorder. International clinical psychopharmacology [Internet]. 2020 May 1 [cited 2024 Jan 20];35(3):129–36. Available from: https://pubmed.ncbi.nlm.nih.go....
 
49.
Muñoz-Negro JE, Cervilla JA. A Systematic Review on the Pharmacological Treatment of Delusional Disorder. Journal of clinical psychopharmacology [Internet]. 2016 Dec 1 [cited 2024 Jan 20];36(6):684–90. Available from: https://pubmed.ncbi.nlm.nih.go....
 
50.
González-Rodríguez A, Estrada F, Monreal JA, Palao D, Labad J. A Systematic Review of Methods for the Measurement of Antipsychotic Adherence in Delusional Disorder. Journal of clinical psychopharmacology [Internet]. 2018 Aug 1 [cited 2024 Jan 20];38(4):412–4. Available from: https://pubmed.ncbi.nlm.nih.go....
 
51.
Lähteenvuo M, Taipale H, Tanskanen A, Mittendorfer-Rutz E, Tiihonen J. Effectiveness of pharmacotherapies for delusional disorder in a Swedish national cohort of 9076 patients. Schizophrenia research [Internet]. 2021 Feb 1 [cited 2024 Jan 20];228:367–72. Available from: https://pubmed.ncbi.nlm.nih.go....
 
52.
Sajatovic M, Mbwambo J, Lema I, Blixen C, Aebi ME, Wilson B, et al. Correlates of poor medication adherence in chronic psychotic disorders. BJPsych Open [Internet]. 2021 Jan [cited 2024 Jan 20];7(1). Available from: /pmc/articles/PMC7791569/.
 
53.
Vita A, Barlati S, Ceraso A, Nibbio G, Ariu C, Deste G, et al. Effectiveness, Core Elements, and Moderators of Response of Cognitive Remediation for Schizophrenia. JAMA Psychiatry. 2021 Aug;78(8):848.
 
54.
Freeman D, Dunn G, Startup H, Pugh K, Cordwell J, Mander H, et al. Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): a parallel, single-blind, randomised controlled trial with a mediation analysis. The Lancet Psychiatry. 2015 Apr;2(4):305–13.
 
55.
Freeman D, Emsley R, Diamond R, Collett N, Bold E, Chadwick E, et al. Comparison of a theoretically driven cognitive therapy (the Feeling Safe Programme) with befriending for the treatment of persistent persecutory delusions: a parallel, single-blind, randomised controlled trial. The Lancet Psychiatry. 2021 Aug;8(8):696–707.
 
56.
Andreou C, Wittekind CE, Fieker M, Heitz U, Veckenstedt R, Bohn F, et al. Individualized metacognitive therapy for delusions: A randomized controlled rater-blind study. Journal of Behavior Therapy and Experimental Psychiatry. 2017 Sep;56:144–51.
 
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