Aim: to investigate the etiology, pathogenesis, and effectiveness of pharmacotherapy and psychotherapeutic modalities of delusions in Schizophrenia spectrum and other Psychotic Disorders. Methods: In our study, we included English-language studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library conducted until January 2024 using the following keywords “delusions”, “Schizophrenia spectrum and other Psychotic Disorders”, “pharmacotherapy”, “psychotherapy”, and “antipsychotics”. Scientific novelty: There is already published evidence that has studied Schizophrenia spectrum disorders from definition to treatment. However, a lack of studies has identified a comprehensive analysis of the available therapies for managing this condition. In our article, we studied Schizophrenia spectrum disorders and evaluated the role of both pharmacotherapy and psychotherapy in managing this condition. Conclusion: The management of delusions requires combined pharmacotherapy and psychotherapy. Cognitive therapy combined with antipsychotics has a significant beneficial role in improving delusions. Further randomized trials are required to properly estimate the efficacy of the available therapies and determine the first-choice therapy in patients with different categories of Schizophrenia spectrum disorders.