Aim:
Aims: to compare the results of use of vancomycin powder in the prevention of wound infection in operations of hip replacement that is total to a control group.

Material and methods:
Patients and methods: 40 patients undergoing total hips arthroplasty during period (January 2021 to January 2022). Patients were allocated in a random way into two categories so that one group received vancomycin powder and served a study group; the other group received no such intervention and served as a control group. Patients underwent steps: after completion of surgery, regular closure in layers was done; drain was inserted into sub-muscular layers while vancomycin powder (1 gm) was put in subcutaneous layer before skin closure; drain was closed for two hours and then reopened.

Results:
Results: Superficial infection was seen in 1(5.0%) and 2(10.0%), in vancomycin category & group of control and variation was insignificant statistically (p=1.0). Deep infection was seen in 0(0.0%) and 3(15.0%), in vancomycin category and group of control, and variation was insignificant statistically (p=0.231). Wound complication was seen in 2(10.0%) and 0(0.0%), in vancomycin group and group of control, respectively and variation was insignificant statistically (p=0.487). Return to operating room was seen in 1(5.0%) and 1(5.0%), in vancomycin category and category of control, respectively and variation was insignificant statistically (p=1.0). Peri-prosthetic fracture was not reported.

Conclusions:
Conclusion: Utilization of powder of vancomycin is safe and efficient way in preventing deep wound infection accompanying total hip arthroplasty but small sample size herein suggested need for further future studies to validate our results.