Aim:
To study xylate effect on the renal toxin-excreting function with diabetes mellitus (DM) complicated by endogenous intoxication syndrome of purulent-septic genesis.

Material and methods:
The effect of infusions with sorbilact or Ringer’s solution in the regimen 3 ml/kg/hour during 3 hours on toxin-excreting function of the kidneys in patients with type 2 DM complicated by EIS is studied.

Results:
In the period of the research, xylate increased cleaning blood plasma (extracellular water space) from the total toxicity by 6,0±1,9 ml/min (230±72,3%, Δ р<0,05). Ringer’s solution infusion in the fragment of intensive care of the same group of patients (n=53) was determined by increase of clearance of toxic substances by 4,3±1,2 ml/min (165±46,0%, Δ р<0,05). At the same time, xylate infusion decreased the total blood plasma toxicity by 22±4,6 IU/ml (14±2,9%, Δ р<0,05), and Ringer’s solution – by 12±3,9 IU/ml (7±2,2%, Δ р<0,05).

Conclusions:
Infusion therapy solutions (xylate, Ringer's solution) within the study regimen (3 ml/kg/h for three hours) activate the renal excreting function and reduce the level of toxemia (xylate > Ringer's solution) in patients with Type 2 DM complicated by endogenous intoxication syndrome of purulent-septic genesis. At the same time, xylate infusion reduced the total plasma toxicity by 22±4.6 IU/ml (14±2.9%, Δ p<0.05), Ringer's solution - by 12±3.9 IU/ml (7±2.2%, Δ p<0.05).